What are Protein Interactions?
Physical contact between two or more proteins with high specificity resulting of biochemical pathways associated with a biological function.
PAX8 Protein Interaction Across Human Body
PAX8 most notable biological interactions and functions are associated with the thyroid gland. A functional thyroid gland a wild type PAX8 gene interact with other proteins that contribute to organ systems.
Pax8 Interactions Across Thyroid Gland
Molecular Pathway: The main function of PAX8 is to assist in the development of the Thyroid Stimulating Hormone Receptor (TSHR) located on thyroid gland tissue. [1] Without TSHR the production thyroid hormone Thyroxine and Triiodothyronine are responsible regulating metabolism from infancy to adulthood.
PAX8 Protein Interaction Differ Among Mammals
Human |
Mice |
Protein Key: Biological functions
Discussion:
With the use of String we able to confirm the existence of protein-protein interactions between PAX8 and TSHR in the biological function of thyroid gland development. In many individuals with Congenital Hypothyroidism with reduced or ruminates of a thyroid gland have the potential risk of developing thyroid cancer as some proteins such as Pparg and TTF1 can still be transcribed and translated into proteins. [2] However with no receptors or lower binding affinities such as Rxrb can lead to unspecific bind to wrong substrates resulting in Cancer.
References:
[1]Chi, Neil, and Jonathan A. Epstein. "Getting your Pax straight: Pax proteins in development and disease." TRENDS in Genetics 18.1 (2002): 41-47.
[2] Xu, Bin, et al. "Adipogenic Differentiation of Thyroid Cancer Cells Through the Pax8-PPARγ Fusion Protein Is Regulated by Thyroid Transcription Factor 1 (TTF-1)." Journal of Biological Chemistry 291.37 (2016): 19274-19286.
[2] Xu, Bin, et al. "Adipogenic Differentiation of Thyroid Cancer Cells Through the Pax8-PPARγ Fusion Protein Is Regulated by Thyroid Transcription Factor 1 (TTF-1)." Journal of Biological Chemistry 291.37 (2016): 19274-19286.